dissoBOT®
Automated dissolution system
dissoBOT®
The world's first fully automated dissolution system with clip-on/off capability.
Advanced dissolution automation is built around world’s leading dissolution system – Agilent 708-DS Dissolution Apparatus and Agilent 850-DS Dissolution Sampling Station and optional filtration module.
Working principle
Latest technology in collaborative robotics
Advanced automation is performed with the help of the latest technology in collaborative robotics. The clip-on/off capability enables users to extend their working cycles on existing dissolution systems. There is no interference in the dissolution process and the clip-on procedure takes less than a minute. DissoBOT® system takes over the control of the dissolution apparatus and sampling station.
Working principle
Fully automated cycles
Advanced dissolution automation technology of dissoBOT® performs fully automated sequential cycles of cleaning, media dispensing, and introduction of new dosage forms to the dissolution apparatus.
The dissolution process
Automatically activated dissolution process.
When dissoBOT® takes care of cleaning, media dispensing and dosage forms introduction, it is time for a dissolution process. The Dosage Delivery Module (DDM) is activated automatically. The dissolution itself is performed with standard 708-DS Dissolution Apparatus featuring a smooth-operating, motorized lift for reproducibility and integration with automated systems. Sampling is performed with an automated sampling manifold using the 850- DS Dissolution Sampling Station and optional filtration module. The system collects samples into test tubes, HPLC vials or well plates for subsequent analysis. Temperature is monitored with precise invessel monitoring AutoTemp. The individual vessel values may be documented initially, at each pre-programmed time point, and after the test has concluded.
Highlights
System Functionality
Overview
- Clip-on/off platform with table-top collaborative robot
- Sequential cleaning, media dispensing and samples introduction
- Standard Agilent 708-DS Dissolution Apparatus and 850-DS Dissolution Sampling Station
- Suitable for Apparatus 2 (paddles) and Apparatus 1 (baskets)
- Internal tanks and external connections
Technical information
Specifications
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Suitable for Methods
Apparatus 2 (paddles) and Apparatus 1 (baskets)
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Media Types
Compatible with all typical dissolution media containing surfactants
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Number of Working Positions
Up to 6 vessels
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Number of Samples
Up to 8 batches of 6 samples
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Number of Sampling Points
Up to 16
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Internal Rinse Container
47 l (12.4 gal)
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Internal Media Container
47 l (12.4 gal)
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External Waste Container
100 l (26.4 gal) – optional
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External Rinse Connection
Optional
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External Media Connection
Optional
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Media Dispense Principle
Volumetric media dispensing with dissoDOSE® technology
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Media Dispensing Accuracy
< 1% (range from 400 ml to 1000 ml dispense)
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Suitable for Methods
Apparatus 2 (paddles) and Apparatus 1 (baskets)
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Media Types
Compatible with all typical dissolution media containing surfactants
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Filtration Options
Cannula filters: 10, 35, and 70 μm; Filter plates: 0.45 μm
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Media Replacement
Standard, up to 100% of sample removed
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Sampling Accuracy
10 mL 2.5%
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Sample Volume per Vial/Tube
0.1–14 mL (up to 28 mL with dual sample)
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Sample Frequency
Method specific with minimum of 2 minutes
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Evaporation
Less than 1% evaporative loss under specific conditions
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Water Bath Temperature Range
Ambient +5 to 55 °C
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Probe Accuracy
0.1 °C
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Spindle Speed Range
10-250 RPM
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Speed Accuracy
1% over 25 RPM, 2% 10-25 RPM
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Speed Selection
Motorized drive
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Spindle Shaft Material
Stainless steel
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Dissolution Drive Unit Lift
Dosage Delivery Module (DDM), Autosampling, AutoTemp
dissoBOT®
Advanced Dissolution
Automation Module
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Operating Height
190 cm
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Operating Width
135 cm
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Operating Depth
70 cm
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Weight (Machine Dry)
50 kg
dissoBOT®
Advanced Dissolution
Automation Module
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Width
62.2 cm
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Operating Height
67.95 cm
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Clearance Height
99.06 cm
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Depth
59 cm
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Weight
54.4 kg
dissoBOT®
Advanced Dissolution
Automation Module
-
Operating Height
190 cm
-
Operating Width
135 cm
-
Operating Depth
70 cm
-
Weight (Machine Dry)
50 kg
Brochure
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dissoBOT®