dissoBOT®

dissoBOT®

Automated dissolution system

merel instruments

dissoBOT®

merel instruments

The world's first fully automated dissolution system with clip-on/off capability.

Advanced dissolution automation is built around world’s leading dissolution system – Agilent 708-DS Dissolution Apparatus and Agilent 850-DS Dissolution Sampling Station and optional filtration module.

Working principle

Latest technology in collaborative robotics​

Advanced automation is performed with the help of the latest technology in collaborative robotics. The clip-on/off capability enables users to extend their working cycles on existing dissolution systems. There is no interference in the dissolution process and the clip-on procedure takes less than a minute. DissoBOT® system takes over the control of the dissolution apparatus and sampling station.

merel instruments

Working principle

Fully automated cycles

Advanced dissolution automation technology of dissoBOT® performs fully automated sequential cycles of cleaning, media dispensing, and introduction of new dosage forms to the dissolution apparatus.

Highlights

System Functionality
Overview

The dissolution process

Automatically activated dissolution process.

When dissoBOT® takes care of cleaning, media dispensing and dosage forms introduction, it is time for a dissolution process. The Dosage Delivery Module (DDM) is activated automatically. The dissolution itself is performed with standard 708-DS Dissolution Apparatus featuring a smooth-operating, motorized lift for reproducibility and integration with automated systems. Sampling is performed with an automated sampling manifold using the 850- DS Dissolution Sampling Station and optional filtration module. The system collects samples into test tubes, HPLC vials or well plates for subsequent analysis. Temperature is monitored with precise invessel monitoring AutoTemp. The individual vessel values may be documented initially, at each pre-programmed time point, and after the test has concluded.

Highlights

System Functionality
Overview

Technical information

Specifications

  • Suitable for Methods

    Apparatus 2 (paddles) and Apparatus 1 (baskets)

  • Media Types

    Compatible with all typical dissolution media containing surfactants

  • Number of Working Positions

    Up to 6 vessels

  • Number of Samples

    Up to 8 batches of 6 samples

  • Number of Sampling Points

    Up to 16

  • Internal Rinse Container

    47 l (12.4 gal)

  • Internal Media Container

    47 l (12.4 gal)

  • External Waste Container

    100 l (26.4 gal) – optional

  • External Rinse Connection

    Optional

  • External Media Connection

    Optional

  • Media Dispense Principle

    Volumetric media dispensing with dissoDOSE® technology

  • Media Dispensing Accuracy

    < 1% (range from 400 ml to 1000 ml dispense)

  • Suitable for Methods

    Apparatus 2 (paddles) and Apparatus 1 (baskets)

  • Media Types

    Compatible with all typical dissolution media containing surfactants

  • Filtration Options

    Cannula filters: 10, 35, and 70 μm; Filter plates: 0.45 μm

  • Media Replacement

    Standard, up to 100% of sample removed

  • Sampling Accuracy

    10 mL 2.5%

  • Sample Volume per Vial/Tube

    0.1–14 mL (up to 28 mL with dual sample)

  • Sample Frequency

    Method specific with minimum of 2 minutes

  • Evaporation

    Less than 1% evaporative loss under specific conditions

  • Water Bath Temperature Range

    Ambient +5 to 55 °C

  • Probe Accuracy

    0.1 °C

  • Spindle Speed Range

    10-250 RPM

  • Speed Accuracy

    1% over 25 RPM, 2% 10-25 RPM

  • Speed Selection

    Motorized drive

  • Spindle Shaft Material

    Stainless steel

  • Dissolution Drive Unit Lift

    Dosage Delivery Module (DDM), Autosampling, AutoTemp

dissoBOT®

Advanced Dissolution
Automation Module

  • Operating Height

    190 cm

  • Operating Width

    135 cm

  • Operating Depth

    70 cm

  • Weight (Machine Dry)

    50 kg

dissoBOT®

Advanced Dissolution
Automation Module

  • Width

    62.2 cm

  • Operating Height

    67.95 cm

  • Clearance Height

    99.06 cm

  • Depth

    59 cm

  • Weight

    54.4 kg

dissoBOT®

Advanced Dissolution
Automation Module

  • Operating Height

    190 cm

  • Operating Width

    135 cm

  • Operating Depth

    70 cm

  • Weight (Machine Dry)

    50 kg

Brochure

Want to know more?

Get insights into the features, specifications, and benefits of our product. Click the link below to access the brochure with details.
merel instruments

dissoBOT®

The world's first fully automated dissolution system with clip-on/off capability.

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