dissoBOT®
Automated dissolution system
dissoBOT®
The world's first fully automated dissolution system with clip-on/off capability.
Advanced dissolution automation is built around world’s leading dissolution system – Agilent 708-DS Dissolution Apparatus and Agilent 850-DS Dissolution Sampling Station and optional filtration module.
Working principle
Latest technology in collaborative robotics
Advanced automation is performed with the help of the latest technology in collaborative robotics. The clip-on/off capability enables users to extend their working cycles on existing dissolution systems. There is no interference in the dissolution process and the clip-on procedure takes less than a minute. DissoBOT® system takes over the control of the dissolution apparatus and sampling station.
Working principle
Fully automated cycles
Advanced dissolution automation technology of dissoBOT® performs fully automated sequential cycles of cleaning, media dispensing, and introduction of new dosage forms to the dissolution apparatus.
The dissolution process
Automatically activated dissolution process.
When dissoBOT® takes care of cleaning, media dispensing and dosage forms introduction, it is time for a dissolution process. The Dosage Delivery Module (DDM) is activated automatically. The dissolution itself is performed with standard 708-DS Dissolution Apparatus featuring a smooth-operating, motorized lift for reproducibility and integration with automated systems. Sampling is performed with an automated sampling manifold using the 850- DS Dissolution Sampling Station and optional filtration module. The system collects samples into test tubes, HPLC vials or well plates for subsequent analysis. Temperature is monitored with precise in-vessel monitoring AutoTemp. The individual vessel values may be documented initially, at each pre-programmed time point, and after the test has concluded.
Highlights
System Functionality
Overview
- Clip-on/off platform with table-top collaborative robot
- Sequential cleaning, media dispensing and samples introduction
- Standard Agilent 708-DS Dissolution Apparatus and 850-DS Dissolution Sampling Station
- Suitable for Apparatus 2 (paddles) and Apparatus 1 (baskets)
- Internal tanks and external connections
Technical information
Specifications
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Number of Working Positions
Up to 6 vessels
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Number of Samples
Up to 8 batches of 6 samples
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Number of Sampling Points
Up to 16
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Internal Rinse Container
47 L (12.4 gal)
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Internal Media Container
47 L (12.4 gal)
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External Waste Container
100 L (26.4 gal) – optional
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External Rinse Connection
Optional
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External Media Connection
Optional
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Media Dispense Principle
Volumetric media dispensing with dissoDOSE® technology
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Media Dispensing Accuracy
< 1% (range from 400 mL to 1000 mL dispense)
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Suitable for Methods
Apparatus 2 (paddles) and Apparatus 1 (baskets)
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Media Types
Compatible with all typical dissolution media containing surfactants
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Filtration Options
Cannula filters: 10, 35, and 70 μm; Filter plates: 0.45 μm
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Media Replacement
Standard, up to 100% of sample removed
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Sampling Accuracy
10 mL 2.5%
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Sample Volume per Vial/Tube
0.1–14 mL (up to 28 mL with dual sample)
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Sample Frequency
Method specific with minimum of 2 minutes
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Evaporation
Less than 1% evaporative loss under specific conditions
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Water Bath Temperature Range
Ambient +5 to 55 °C
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Probe Accuracy
0.1 °C
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Spindle Speed Range
10-250 RPM
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Speed Accuracy
1% over 25 RPM, 2% 10-25 RPM
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Speed Selection
Motorized drive
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Spindle Shaft Material
Stainless steel
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Dissolution Drive Unit Lift
Dosage Delivery Module (DDM), Autosampling, AutoTemp
dissoBOT®
Advanced Dissolution
Automation Module
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Operating Height
190 cm
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Operating Width
135 cm
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Operating Depth
70 cm
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Weight (Machine Dry)
50 kg
dissoBOT®
Advanced Dissolution
Automation Module
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Width
62.2 cm
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Operating Height
67.95 cm
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Clearance Height
99.06 cm
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Depth
59 cm
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Weight
54.4 kg
dissoBOT®
Advanced Dissolution
Automation Module
-
Operating Height
190 cm
-
Operating Width
135 cm
-
Operating Depth
70 cm
-
Weight (Machine Dry)
50 kg
Brochure
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dissoBOT®